Guess at this place it is a must to briefly describe the biochemical
importance of isoprenoids in primary and secondary metabolism, their
implication in a myriad of physiological processes notably in plants,
microorganisms and parasites, their biological activities at the
cellular, organism and ecosystem levels. Thus, there exists
considerable interest in the elucidation, subcellular compartmentation
and interaction of biosynthetic pathways and in the development of
branch-specific inhibitors as mother compounds for the development of
antiparasitic drugs (malaria!), bactericides and herbicides. Other
attempts are directed at overproduction of pharmaceutically interesting
compounds such as the anticancer agent taxol or the antimalaria agent
artemisinine. Further aspects to be touched on are isoprenoid
“neutraceuticals”, for instance plants synthesizing and accumulating
high amounts of the isoprenoid antioxidant vitamin E (a-tocopherol),
provitamin A (ß-carotene) and vitamin K (phylloquinone). Another topic
will be the structural elucidation of enzymes involved in isoprenoid
biosynthesis, isolated from plants, microorganisms and parasites, for
instance to identify structural components in enzymes that are
regulated by feedback control. We could imagine that all these
arguments should raise your interest, not excluding further exciting
aspects to be discussed |  |
TERPNET
2007 Meeting Strasbourg - Scientific and Social Program
Monday, April 30: 10:00 to 14:00 Inscription and
poster fixing; coffee, beverages… 14:15 to 14:45 Opening
addresses 15:00 to 15:45 General Lecture Olivier VOINNET: How to exploit RNA silencing: Advantages and limits 16:00 to 17:40 BIOTECHNOLOGY
AND NUTRITION
Chair: Albert Boronat & David Hallahan L1 Eleanore
T. WURTZEL: Regulation of provitamin A
carotenoid accumulation in cereal crops
(20 min) L2 Jack
NEWMAN: Production of artemisinin via microbial fermentation and chemical
transformation (20 min) L3 Jens
SCHRADER: AtCCD1, a carotenoid cleavage
dioxygenase from A. thaliana, as highly selective in vitro
biocatalyst (15 min) L4 Sun-Hwa
HA: Carotenoid accumulation by two
bicistronic gene expression systems using the 2A and IRES sequences in rice
grain (15 min) L5 Alain
TISSIER: Engineering tobacco trichomes for
the production of heterologous diterpenoids and sesquiterpenoids (15 min) L6 Sydnor
T. WITHERS: Production of marine diterpenoids
in culture (15 min) 17:40 to 18:15 HORMONES Chair: Yuji KAMIYA & Michel ROHMER L7 Reuben
J. PETERS: To gibberellins and beyond!
(20 min) L8 Kai
AMENT: Geranyl diphosphate synthase is required for the biosynthesis of
gibberellins (15 min) 18:15 to 18:50 PROTEIN
PRENYLATION
Chair:
Yuji KAMIYA & Michel ROHMER L9 Dring
N. CROWELL: Arabidopsis thaliana plants possess a
specific farnesylcysteine lyase that is involved in detoxification and
recycling of farnesylcysteine (20
min) L10 Nathalie Giglioli-Guivarc’h: CaaX-prenyltransferases are
essential for monoterpenoid biosynthesis in Catharanthus roseus (15 min) Tuesday,
May 1 08:30 to 09:00 Late inscription and
poster fixing 09:00 to 10:25 ENZYME
STRUCTURES AND MECHANISMS (1)
Chair: Jonathan Gershenzon & Peter BRODELIUS L11 Cynthia
STAUFFACHER: Examining enzyme mechanism and inhibition in the isoprenoid
biosynthesis pathway: Crystallographic studies of HMG-CoA synthase and HMG-CoA
reductase (20 min) L12 Felix ROHDICH: Perspectives in
anti-infective drug development: Biosynthesis of the universal isoprenoid
precursors, isopentenyl diphosphate and dimethylallyl diphosphate (20 min) L13 Liang TONG: Crystal structure of
1-deoxy-D-xylulose 5-phosphate synthase (DXS) (15 min) L14 Florence POJER: Structural basis for
the design of potent and species specific inhibitors of
3-hydroxy-3-methylglutaryl coenzyme A synthases (15 min) L15 C. Dale POULTER: A study of the
mechanism of the isomerization catalyzed by type II isopentenyl diphosphate
isomerase (15 min) 10:25 to 11:10 Coffee break and
poster viewing 11:10 to 13:00 ENZYME
STRUCTURES AND MECHANISMS (2)
Chair: Wolfgang Eisenreich & Hassan JOMAA L16 W. David NES: Protein engineering
and thermodynamic analyses to understand catalytic promiscuity and sterol
evolution (20 min) L17 Ikuro ABE: Enzymatic synthesis of
unnatural cyclic triterpenes
(20 min) L18 Rudolf K.
ALLEMANN: Strategies for the manipulation of carbocations by aristolochene synthase (20 min) L19 Robert COATES: Aza and fluoro
terpenes: Useful analogues for investigations on terpene synthases (15 min) L20 Joe CHAPPELL: Unraveling the
catalytic specificity of terpene hydroxylases and engineering sesquiterpene
metabolism in plants (15 min) L21 Michel MATRINGE:
Modulation of vitamin E biosynthesis in planta: importance of the
regulation of the branch point between phenylalanine and tyrosine
biosynthesis (20 min) 13:15 to 14:30 Lunch 14:50 to 16:00 PATHWAYS
AND REGULATION (1)
Chair:
Joe Chappell & Natalia Dudareva L22 Patricia LEÓN: Transcriptional and
post-transcriptional mechanisms are important for proper regulation of the
limiting step in the plant MEP pathway
(20 min) L23 Narciso CAMPOS: Post-translational
control of Arabidopsis HMG-CoA reductase by calcium and
protein phosphatase 2A (15 min) L24 Michael WALTER: Divergent
1-deoxy-D-xylulose 5-phosphate synthase (DXS) isogenes control housekeeping or
secondary isoprenoid precursor supply in plastids: a tool to selectively
manipulate endproducts (15 min) L25 Corinne
RIVASSEAU: Cadmium effect on the methylerythritol phosphate (MEP) pathway for
isoprenoid synthesis (15 min) L26 Michael A.
PHILLIPS: Arabidopsis IDI1 and IDI2 encode IPP isomerases that play distinct metabolic
Roles and are targeted to different subcellular compartments (15 min) 16:00 to 17h00 Coffee
break, poster viewing 17h00 to 18:30 PATHWAYS
AND REGULATION (2)
Chair: Eleanore
Wurtzel & Albert Ferrer L27 Francis X.
CUNNINGHAM: A new route to red: Biosynthesis of astaxanthin in the flowers of Adonis (20 min) L28 Toshiya MURANAKA: Comprehensive analysis
of KO-mutants of sterol backbone synthesis toward understanding gametophyte
development (20 min) L29 Kiyoshi OHYAMA: Biosynthetic pathway
of phytosterols via lanosterol in Arabidopsis (15 min) L30 Johan MEMELINK: Transcriptional
regulation of monoterpenoid indole alkaloid biosynthesis in Catharanthus
roseus (20 min) L31 Benoit St
PIERRE: Spatial organisation of the monoterpene indole alkaloid pathway in Catharanthus
roseus (15
min) Wednesday, May 2 08:45 to 10:20 VOLATILES,
SCENTS, AROMES, DEFENSE, TRANSPORT (1)
Chair: Anand Akhila
& Werner Knöss L32 Natalia DUDAREVA: Involvement
of compartmentalization in nerolidol and linalool biosynthesis in snapdragon
flowers (20 min) L33 Dorothea
THOLL: Elucidating the formation of geranyllinalool, the first committed step
in the biosynthesis of the volatile C16-homoterpene TMTT involved in
indirect plant defense (15 min) L34 Jörg DEGENHARDT: A maize (E)-b-caryophyllene synthase
attracts herbivore enemies towards different herbivores above and below
ground (15 min) L34a Jonathan
Gershenzon: The role of plant
sesquiterpenes in resistance to oxidative stress (15 min) L35 Roland MUMM: Significance of
volatile terpenoids in plant defense against herbivorous arthropods (15 min) L36 Xiaoquan
QI: Functional characterization of a monocot-specific cytochrome P450 that
is required for the synthesis of defence-related triterpenes in cereals (15 min) 10:20 to 11:25 Coffee break and poster
viewing 11:25 to 13:00 VOLATILES,
SCENTS, AROMES, DEFENSE, TRANSPORT (2)
Chair: Alain Tissier
& Jean-Claude CAIssard L37 Claudia E.
VICKERS: Molecular characterisation of isoprene synthase in poplar and
transgenic tobacco (15 min) L38 Barbara EHLTING: Some like it hot, some
don’t (15 min) L39 Csengele
BARTA: Arabidopsis transformed to emit isoprene are more resistant to high
light and high temperatures and show a different intracellular redox balance
than non-emitting wild types (15
min) L40 Carolien
Ruyter-Spira: Terpenoid rhizosphere signaling (15 min) L41 Emmanuel
PEETERS: Transport of terpenoids out of tobacco cells by pleiotropic drug
resistant transporters (15
min) L42 Anne OSBOURN: A gene cluster in oat
confers resistance to take-all and other soil-borne diseases (20 min) 13:15 to 14:30 Lunch 14:50 to 15:40 Poster viewing 16:00 to
17:30 Boat tour (Ile de
Strasbourg, European Institutions) 17:30
to 18:30 Guided tour (Strasbourg Cathedral…) 18:45
to 20:00 Reception at the City Hall (Place Broglie)
Thursday, May 3 09:00 to 10:10 RUBBER
AND POLYPRENOLS
Chair:
C. Dale Poulter & Andréa
HEMMERLIN L43 Ewa SWIEZEWSKA: Polyisoprenoids: structure, biosynthesis and function (20 min) L44 Pluang
SUWANMANEE: Expression of HMG-CoA synthase (hmgs) and HMG-CoA reductase-1 (hmgr-1)
reveals coordinated regulation of rubber biosynthesis in Hevea brasiliensis (B.H.K.) Müll. Arg (20 min) L45 Tanetoshi
KOYAMA: cis-Prenyltransferases for natural rubber biosynthesis in Hevea
brasiliensis Latex (15 min) L46 Maureen
WHALEN: Development of crops to produce industrially useful natural
rubber (15 min) 10:10 to 11:00 Coffee
break and poster viewing 11:00 to 13:05 PHARMACEUTICAL ASPECTS
Chair: Benoît St-Pierre &
Manuel Rodríguez-Concepción L47 Werner KNÖSS: Plant
Isoprenoids in Medicinal Products
(15 min) L48 Anand AKHILA: Scope and strategies of transgenic manipulation of isoprenoid (C10
and C15) biosynthesis in plants producing aroma and medicinal
compounds (15 min) L49 Pamela J.
WEATHERS: Artemisinin: controlling its
production in Artemisia annua (20 min) L50 Maggie SMALLWOOD: Fast-track breeding of Artemisia annua (15 min) L51 Wolfgang
KREIS: Cloning and heterologous expression of a recombinant progesterone 5b-reductase (5b-POR), supposed to be a
key enzyme in cardenolide biosynthesis, from the cardenolide-free angiosperm Arabidopsis
thaliana (15 min) L52 David L.
HALLAHAN: Refined oil of Nepeta cataria: a new safe and
effective insect repellent active ingredient (15 min) L53 S.P. SINHA BABU: Acaciasides and
its possible role in the control of lymphatic filariasis (15 min) L54 Hassan JOMAA: Preclinical
development of the fosmidomycin derivative FR-900098 (15 min) 13:15 to 14:30 Lunch 14:50 to 17:00 Poster
discussion 17:30 to 23:00 Excursion
(Alsace region, wine tasting and congress dinner) Friday,
May 409:00 to 10:45 “OMICS”
Chair:
Dring N. CROWELL & Hubert
SCHALLER L55 David GANG: Control of Metabolism
in Medicinal Plants (20 min) L56 Jim BRANDLE: Using functional
genomics to characterize the biosynthesis and transport of the sweet glycosides
of Stevia rebaudiana (20 min) L57 Soheil S. MAHMOUD: Regulation of
essential oil metabolism in lavenders using a genomics approach (15 min) L58 Yuji KAMIYA: High-sensitive and
high-throughput plant hormone analysis by LC-MS/MS (20 min) L59 Jürgen EHLTING: A bioinformatics
meta-approach to map the P450 superfamily onto metabolic pathways based on
public expression data (15 min) L60 Daisaku OHTA: Plant cytochromes P450
involved in the biosynthesis of D22-sterols (15 min) 10:45 to 11:30 Coffee
break and posters 11:30 to 13:00 General discussion
and closure of the meeting 13:15 to 14:30 Lunch
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